TMTC1 Antibody, FITC conjugated

Code CSB-PA808537LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TMTC1 Polyclonal antibody
Uniprot No.
Target Names
TMTC1
Alternative Names
TMTC1 antibody; ARG99 antibody; Protein O-mannosyl-transferase TMTC1 antibody; EC 2.4.1.109 antibody; Transmembrane and TPR repeat-containing protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Transmembrane and TPR repeat-containing protein 1 protein (1-227AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3.
Gene References into Functions
  1. O-mannosylation pathway dedicated to cadherins/ protocadherins orchestrated by the four TMTC1-4 genes PMID: 28973932
  2. findings provide an important link between aneuploidy and the stress pathways activated by Aurora B inhibition and also support the use of Aurora B inhibitors in combination therapy for treatment of cancer. PMID: 24764305
Subcellular Location
Membrane; Multi-pass membrane protein. Endoplasmic reticulum.
Protein Families
TMTC family
Database Links

HGNC: 24099

OMIM: 615855

KEGG: hsa:83857

STRING: 9606.ENSP00000442046

UniGene: Hs.401954

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